ASSIGNMENT: CASE STUDIES
Case studies are a useful way for you to apply your knowledge of pharmacokinetics and pharmacodynamic aspects of pharmacology to specific patient cases and health histories.
For this Assignment, you evaluate drug treatment plans for patients with various disorders and justify drug therapy plans based on patient history and diagnosis.
RESOURCES
Be sure to review the Learning Resources before completing this activity.
Click the weekly resources link to access the resources.
To Prepare:
- Review the case study posted in Announcements by your Instructor for this Assignment
- Review the information provided and answer questions posed in the case study
- When recommending a medication, write out a complete prescription for the medication
- Whenever possible, use clinical practice guidelines in developing your answers when possible
- Include at least three references to support your answer and cite them in APA format.
Note: If you do not purchase Lecturio, please consult these resources for this week.
- Rosenthal, L. D., & Burchum, J. R. (2025). Lehnes pharmacotherapeutics for advanced practice nurses and physician assistants (3rd ed.). Elsevier.
- Chapter 37, Diuretics (pp. 285292)
- Chapter 38, Drugs Acting on the Renin-Angiotensin-Aldosterone System (pp. 292303)
- Chapter 39, Calcium Channel Blockers (pp. 303308)
- Chapter 40, Vasodilators (pp. 308311)
- Chapter 41, Drugs for Hypertension (pp. 311320)
- Chapter 42, Drugs for Heart Failure (pp. 321332)
- Chapter 43, Antidysrhythmic Drugs (pp. 333344)
- Chapter 44, “Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol and Triglyceride Levels” (pp. 345359)
- Chapter 45, Drugs for Angina Pectoris (pp. 360367)
- Chapter 46, Anticoagulant and Antiplatelet Drugs (pp. 368384)
Welcome to Week 2: Cardiovascular System
Happy Monday Morning Class and Welcome to Week 2.In Week 2, we will continue our pharmacology journey and apply the concepts to the cardiovascular system. Pharmacodynamics and pharmacokinetics are the two branches of pharmacology. Remember, pharmacokinetics describes what the body does to the drug through absorption, distribution, metabolism, and excretion (ADME), whereas pharmacodynamics describes what the drug does to the body.When selecting drugs and determining dosages for patients, it is essential to consider individual patient factors that might impact the patients pharmacokinetic and pharmacodynamic processes. These patient factors include genetics, gender, ethnicity, age, behavior (ie diet, nutrition, smoking, alcohol, illicit drug abuse), and/or pathophysiological changes due to disease.Learning Resources: Please plan accordingly throughout the week to review all learning resources that include but not limited to the lecturio resources and all required reading. There is much information provided but all is relevant that you will need not only for the successful completion of this course but also as you begin your practice as a Nurse Practitioner. As well, there are many required media videos for you to view this week and they are very informative.Week 2 Assignment: Please use the following Case Studies to complete your Assignment for this week that is Due by Day 7. Case studies are a useful way for you to apply your knowledge of pharmacokinetics and pharmacodynamic aspects of pharmacology to specific patient cases and health histories.For your Week 2 assignment, evaluate drug treatment plans for patients with various disorders and justify drug therapy plans based on patient history and diagnosis.DIRECTIONS: For each of the scenarios below, answer the questions using your learning resources, Medscape, and clinical practice guidelines (ie JNC 8, AHA, ACC etc). Lecturio is an optional resource but highly recommended. Be sure to thoroughly answer ALL questions. When recommending medications, write out a complete medication order. What would you send to a pharmacy? Include drug, dose, route, frequency, special instructions, # dispensed (days supply) and refill information. Also state if you would continue, discontinue or taper the patients current medications.Review and discuss ALL labs and possible interactions. Use at least 3 sources for each scenario and cite sources using APA format; include in-text citations. You do not need an introduction or conclusion paragraph. Please also review assignment rubric. SCENARIO 1What are the errors in the following prescriptions (1 per prescription)? Rewrite each prescription correctly. What is each medications classification and mechanism of action (MOA)?
- Repatha 140 mg IV every 2 weeks #1 1 RF
- Hyzaar (losartan/hydrochlorothiazide) 50/25 mg PO daily #30 3 RF
- digoxin 1.25 mg PO daily #30 1 RF
- hydralazine/isosorbide mononitrate (BiDil) 37.5 mg/20 mg PO every 8 hours #90 1 RF
- clonidine 0.3 mg patch PO once weekly #4 1 RF
SCENARIO 2A patient with stable angina is prescribed nitroglycerin. The provider avoids oral tablets and instead chooses a sublingual or transdermal formulation. Why is oral nitroglycerin not clinically useful? Discuss how first-pass metabolism affects nitroglycerins bioavailability and define both terms. Identify the route of administration with 100% bioavailability and explain how alternative routes overcome the first pass effect. Include a sample prescription for nitroglycerin.SCENARIO 3Where are the majority of cytochrome P450 (CYP) enzymes located? Using the Drugs.com pill identifier, enter the following characteristics to identify the medication AND strength. What CYP enzyme metabolizes this medication? How can this information be applied to medication therapy management? Write a sample prescription for the identified medication and strength.Imprint (E 137) Shape (Round) Color (Pink) Form (Tablet) Scoring (None) SCENARIO 4KU is a 47-year-old male following up on his labs that were drawn last week. He smokes 1 pack per day. He is currently on lisinopril 40 mg po daily, liraglutide (Victoza) 0.6 mg subcutaneously once daily and St. Johns Wort. Fasting lipid profile shows total cholesterol 260 mg/dL, LDL 180 mg/dL, HDL 43 mg/dL, and TG 185 mg/dL. He is 59 and weighs 204 lbs. What treatment plan would you implement for KU? What are GOAL Total Cholesterol (TC), HDL, LDL, and Triglyceride levels for KU? What is his BMI per Medscape calculator? What patient monitoring and education would you provide? How many risk factors for coronary artery disease does this patient have? Identify them specifically.Also, it will be very helpful to view the rubric for each assignment to ensure you’ve included all requirements before submission.Please let me know if you have any questions by posting in the Class Cafe’, Inbox, or please feel free to email me.I look forward to and am excited about all that we will learn in Week 2!
- please also attach the turnitin score! thanks!
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