6521C Assignment 2

WEEK 2 ASSIGNMENT (covers weeks 1-2)

SCENARIO 1

What are the errors in the following prescriptions (1 per prescription)? Rewrite each

prescription correctly. What is each medications classification and mechanism of action

(MOA)?

Repatha 140 mg IV every 2 weeks #1 1 RF

Hyzaar (losartan/hydrochlorothiazide) 50/25 mg PO daily #30 3 RF

digoxin 1.25 mg PO daily #30 1 RF

hydralazine/isosorbide mononitrate (BiDil) 37.5 mg/20 mg PO every 8 hours #90

1 RF

clonidine 0.3 mg patch PO once weekly #4 1 RF

SCENARIO 2

A patient with stable angina is prescribed nitroglycerin. The provider avoids oral tablets

and instead chooses a sublingual or transdermal formulation. Why is oral nitroglycerin

not clinically useful? Discuss how first-pass metabolism affects nitroglycerins

bioavailability and define both terms. Identify the route of administration with 100%

bioavailability and explain how alternative routes overcome the first pass effect. Include

a sample prescription for nitroglycerin.

SCENARIO 3

Where are the majority of cytochrome P450 (CYP) enzymes located? Using the

Drugs.com pill identifier, enter the following characteristics to identify the medication

AND strength. What CYP enzyme metabolizes this medication? How can this

information be applied to medication therapy management? Write a sample prescription

for the identified medication and strength.

Imprint (E 137) Shape (Round) Color (Pink) Form (Tablet) Scoring (None)

SCENARIO 4

KU is a 47-year-old male following up on his labs that were drawn last week. He

smokes 1 pack per day. He is currently on lisinopril 40 mg po daily, liraglutide (Victoza)

0.6 mg subcutaneously once daily and St. Johns Wort. Fasting lipid profile shows total

cholesterol 260 mg/dL, LDL 180 mg/dL, HDL 43 mg/dL, and TG 185 mg/dL. He is 59

and weighs 204 lbs. What treatment plan would you implement for KU? What are GOAL

Total Cholesterol (TC), HDL, LDL, and Triglyceride levels for KU? What is his BMI per

Medscape calculator? What patient monitoring and education would you provide? How

many risk factors for coronary artery disease does this patient have? Identify them

specifically.

Directions: For each of the scenarios below, answer the questions using your required

learning resources, Medscape, and clinical practice guidelines (ie AHA, ACC, ADA,

GINA). When recommending medications, write out a complete prescription for each

medication. What order would you send to a pharmacy? Include drug, dose, route,

frequency, # dispensed (days supply), refills, special instructions etc. Also state if you

would continue, discontinue or taper the patients current medications (if

applicable). Use at least 3 sources for each scenario and cite sources using APA

format. LIST REFERENCES AFTER EACH SCENARIO.

Case studies are a useful way for you to apply your knowledge of pharmacokinetics and pharmacodynamic aspects of pharmacology to specific patient cases and health histories.

For this Assignment, you evaluate drug treatment plans for patients with various disorders and justify drug therapy plans based on patient history and diagnosis.

Resources

Be sure to review the Learning Resources before completing this activity.

Click the weekly resources link to access the resources.

To Prepare:

• Review the case study posted in Announcements by your Instructor for this Assignment
• Review the information provided and answer questions posed in the case study
• When recommending a medication, write out a complete prescription for the medication
• Whenever possible, use clinical practice guidelines in developing your answers when possible
• Include at least three references to support your answer and cite them in APA format.